Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy: a pilot study
M Chaudhry, M Alessandrini, J Rademan… - …, 2017 - Future Medicine
Aim: Therapy with low-dose amitriptyline is commonly used to treat painful diabetic
peripheral neuropathy. There is a knowledge gap, however, regarding the role of variable
CYP2D6-mediated drug metabolism and side effects (SEs). We aimed to generate pilot data
to demonstrate that SEs are more frequent in patients with variant CYP2D6 alleles. Method:
To that end, 31 randomly recruited participants were treated with low-dose amitriptyline for
painful diabetic peripheral neuropathy and their CYP2D6 gene sequenced. Results …
peripheral neuropathy. There is a knowledge gap, however, regarding the role of variable
CYP2D6-mediated drug metabolism and side effects (SEs). We aimed to generate pilot data
to demonstrate that SEs are more frequent in patients with variant CYP2D6 alleles. Method:
To that end, 31 randomly recruited participants were treated with low-dose amitriptyline for
painful diabetic peripheral neuropathy and their CYP2D6 gene sequenced. Results …
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